Is lexapro activating or sedating
SSRIs block the reuptake of serotonin (5-HT) into the presynaptic nerve terminal, thereby enhancing serotonin neurotransmission, which presumably results in their antidepressant effects.
Although this is the predominant mechanism of action of this class of drugs, each SSRI has a slightly different pharmacologic profile that leads to its distinct clinical activity, side effects, and drug interactions.3 Six SSRIs are currently marketed in the United States; five of them have been approved by the U. Food and Drug Administration (FDA) for the treatment of depression Costs are average wholesale prices for 30 days of the lowest-dose therapy from Red Book. J.: Medical Economics Data, 2002, rounded to the nearest dollar.
In January 2003, fluoxetine was approved by the FDA for the treatment of depression and OCD in children and adolescents who are seven to 17 years of age.6 Because fluoxetine has a half-life of two to four days and its active ingredient, norfluoxetine, has a half-life of seven to nine days, it is reasonable to wait four weeks between dose titrations.
Fluoxetine is now available in a special form taken once-weekly for continuation therapy of depression.
This may be caused by fluoxetine's relative lack of selectivity over norepinephrine and serotonin-2C receptors (5-HT).3 These side effects are short-lived and may improve with a dose reduction or temporary co-administration of a beta-adrenergic blocker or long-acting benzodiazepine.7 Clinically important drug interactions are listed in Any drug that increases serotonin concentrations, including: MAOIs, tramadol (Ultram), sibutramine (Meridia), meperidine (Demerol), sumatriptan (Imitrex), lithium, St. In two studies, male and female outpatients with PTSD who were randomized to 12 weeks of treatment with sertraline experienced significantly more relief from symptoms of avoidance/numbing and hyperarousal than did patients treated with placebo.1314 [References 13 and 14—Evidence level A, RCTs] Intrusive thoughts/re-experiencing phenomena also improved, although the degree of improvement was not statistically significant for each symptom scale.
Cost to patient will be higher depending on filling fees Numerous double-blind, placebo-controlled trials have demonstrated the efficacy of SSRIs in the treatment of depression.It is the only SSRI that is FDA-approved specifically for the treatment of depression in patients who are 65 years of age or older.6 A starting dose of 10 mg per day is preferred in elderly patients, with subsequent titration to 20 mg per day or more.Dosages of 20 to 40 mg per day are commonly required for the treatment of depression; 60 to 80 mg per day may be necessary for the treatment of bulimia and OCD7 . Extended-release venlafaxine has recently been approved by the U. Food and Drug Administration for the treatment of generalized anxiety disorder. New indications for selective serotonin reuptake inhibitors include post-traumatic stress disorder, premenstrual dysphoric disorder, and generalized anxiety disorder.